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Beilstein J. Org. Chem. 2014, 10, 1365–1371, doi:10.3762/bjoc.10.139
Graphical Abstract
Scheme 1: Synthesis of 2-hydroxy-4-pentynoic acid (1).
Scheme 2: Synthesis of 1 via epoxide ring opening with organoalane.
Scheme 3: Attempted synthetic routes for compound 1.
Scheme 4: Synthesis of 2-hydroxy-4-pentynoic acid (1) from diethyl 2-acetamidomalonate.